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KMID : 0613820070170121754
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Journal of Life Science
2007 Volume.17 No. 12 p.1754 ~ p.1759
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Preparation and Characterization of Lactic Acid Bacteria Encapsuled with Alginate Microsphere
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Choi Chang-Yong
Kang Seong-Koo
Park Seok-Kyu
Jang Mi-Kyeong
Nah Jae-Woon
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Abstract
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This study is performed to assess the preparation and characterization of lactic acid bacteria (Sterpoccoccus thermophilus) loaded with alginate microsphere using alginate and chitosan for the efficient delivery of lactic acid bacteria to large intestine. Size and morphology of alginate microsphere were confirmed 6~10 μm with spherical shape by scanning electronic microscope (SEM). Biodegradation study of alginate was investigated at different buffer solutions (pH 1.2 and 7.4). This result showed that alginate microsphere did not degrade at pH 1.2 buffer solution but it's degradation occurred from first day at pH 7.4 buffer solution. Survivability test of lactic acid bacteria in alginate microsphere showed that it was keeping activity of lactic acid bacteria by chroma meter. Therefore, the introduction of alginate microsphere might be a potential system to efficiently delivery lactic acid to large intestine.
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KEYWORD
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Alginate, chitosan, lactic acid bacteria, microsphere
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